Abstract: AIM To compare the application of amlodipine united telmisartan and amlodipine combination amiloride on blood pressure in patients with hypertension and left ventricular hypertrophy, and explore the left ventricular hypertrophy(LVH) and the relationship between serum leptin level. METHODS 92 cases of diagnosed LVH were randomly assigned to amlodipine+amiloride group (46 cases) or amlodipine+telmisartan group (46 cases). Six months after treatment, cardiac morphology, cardiac function and serum leptin level changes were observed in patients. RESULTS Amlodipine + amiloride group and amlodipine+telmisartan group of patients after treatment, systolic blood pressure, diastolic blood pressure, ventricular septal thickness, left ventricular mass, left ventricular mass index, E/A ratio, EF values and serum leptin levels were significantly change (P<0.01 or P<0.05), but between the two groups after treatment systolic pressure, diastolic blood pressure difference was not statistically significant, more than all the differences (P<0.05). CONCLUSION The two groups were significantly lower blood pressure, reverse left ventricular hypertrophy and improve cardiac function and reduce the role of serum leptin level, but the role of amlodipine+telmisartan group even more obvious. Tips for group amlodipine+telmisartan has a better treatment of hypertension, the effectiveness of the protection of the heart and prompt leptin involved in the occurrence of left ventricular hypertrophy, development, and that leptin can be used as observation of changes in hypertensive patients with target.