Abstract: AIM To evaluate the effect of intracoronary injections of adenosine on no-reflow after reperfusion in patients with acute myocardial infarction. METHORDS A total 62 patients treated with PCI were randomly divided into normal group and adenosine group. Corrected thrombolysis in myocardial infarction frame count (cTFC) post-PCI was taken as the criterion and no-reflow was set at cTFC≥23. Before and after PCI, CK-MB and hsCRP were detected and the incidence of no-reflow and the changes of plasma myocardial enzyme and inflammation factors in the two groups were compared. RESULTS The incidence of no-reflow in the adenosine group was obviously lower than that in the normal group (P<0.05). CK-MB and hs-CRP in the normal group was higher than those in the adenosine group (P<0.05). Multivariate line regression analysis showed a prominent correlation between the no-reflow and CK-MB and hsCRP (P<0.05). CONCLUSION The intracoronary injections of adenosine in patients with AMI effectively decreases no-reflow and the levels of myocardial enzyme and inflammation factors.