Abstract: AIM:To observe the influence of shuxuening on high-sensitivity Creactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in patients with unstable angina pectoris (UAP). METHODS: One hundred UAP patients were randomly divided into two groups: control group and therapy group, with 50 cases in each group. For 14 days, the control group was treated with the conventional treatment and the therapy group was treated with a combination of shuxuening (30 ml) with glucose injection (250 ml) once a day in addition to the conventional treatment. The levels of hs-CRP and MMP-9 were detected immediately, 12 h, 24 h, 48 h, 7 days and 14 days after hospitalization. RESULTS: hs-CRP level increased gradually, reached its peak at 24 h after hospitalization, and then decreased. MMP-9 level increased in the first 12 h and then decreased. Compared with those in the control group, levels of hs-CRP and MMP-9 decreased significantly at 12 h, 24 h, 48 h, 7 days and 14 days after hospitalization in the therapy group. CONCLUSION: Shuxuening can maintain the stability of atheromatous plaques by decreasing the levels of hs-CRP and MMP9 in UAP patients.