生长分化因子15在心血管疾病中的研究进展

Research progress in growth differentiation factor 15 and cardiovascular diseases

摘要: 生长分化因子15（GDF-15）是细胞因子超家族转化生长因子β中的成员。在生理条件下GDF-15在心肌中呈弱表达，而在诸多病理条件下其表达水平增加。越来越多的证据表明，GDF-15水平升高是心血管疾病的一种很有价值的预后标志物。此外，GDF-15对心肌细胞具有内源性抗肥厚和拮抗心脏缺血/再灌注损伤的性质。GDF-15正在成为评估和管理心脏病患者的一种很有前途的生物学标志物，并对心肌细胞具有潜在的保护作用。

Abstract: Growth-differentiation factor 15 (GDF-15) is a distant member of the transforming growth factor-β cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions. However, its expression level is increased in response to pathological stress. Growing evidence indicates that the elevated level of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover, GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart from ischemia and reperfusion insult.