阿托伐他汀对犬心房及肺静脉电活动的影响

Effects of atorvastatin on atrial and pulmonary vein electrical activity

摘要: 目的观察阿托伐他汀对犬心房及肺静脉电活动的影响。方法将实验动物犬随机分为对照组(n=7)和试药组(n=7)，其中试药组于术前4周每天服用阿托伐他汀（2 mg/kg）直至术前结束。之后分别测各组犬心房及肺静脉不应期，并进行房颤的诱发。结果试药组犬的心房各部位不应期均较对照组延长，频率适应性较对照组提高。在房颤的诱发中，试药组房颤的诱发率较对照组低。结论阿托伐他汀可有效改善犬的心房电活动，从而对房颤的发生及复发起到抑制作用。

Abstract: AIM To observe the effects of atorvastatin on atrial and pulmonary vein electrical activity. METHODS Fourteen dogs were randomly divided into the control group (n=7) and the atorvastatin group (n=7), and atorvastatin was administered orally (2 mg/kg/day) 4 weeks before operation. The atrial effective refractory period (AERP) and pulmonary vein effective refractory period (AERP) were determined. RESULTS Atorvastatin group had a longer AERP and a longer AERP rate adapting feature. In induced atrial fibrillation, the atorvastin group had a lower rate than the control group. CONCLUSION Atorvastatin effectively improves the atrial electrical activity and reduces the occurrence and recurrence of atrial fibrillation.