Abstract: AIM: To investigate the impact of gender on the prognosis of patients with ST-elevated acute myocardial infarction (STEMI) treated with emergency percutaneous coronary intervention (PCI). METHODS: One hundred and sixty four STEMI patients (130 males vs.34 females) who had been treated with emergency PCI were evaluated on clinical and angiographic characteristics and mortality of all causes during hospitalization. RESULTS: Mean age of women was older than that of men, and women had a higher incidence of diabetes mellitus compared with that of men. LDL-C level of women was also higher than that of men. Rate of smokers and diastolic pressure on admission were lower. No significant difference was observed between genders in mortality, rate of thrombus in infarct-related artery and percentage of TIMI III flow after PCI. CONCLUSION: Gender had no obvious effect on the short-term prognosis of STEMI patients treated with emergency PCI.