Abstract: AIM:To compare the glycosylated hemoglobin (HbA1C) and serum lipid levels in diabetic patients with acute myocardial infarction (AMI) and nondiabetic AMI patients. METHODS: One hundred and thirtytwo AMI patients were divided into two groups: diabetic AMI group (n=92) and nondiabetic AMI group (n=41). Thirtytwo patients without AMI and diabetes served as the control group. Comparison was made in risk factors for coronary artery disease (CAD) and glycosylated hemoglobin and serum lipid levels. RESULTS: No significant difference was found in risk factors for CAD among the three groups. Compared with those in the nondiabetic AMI group and control group, fasting plasma glucose (FPG) levels and HbA1C were higher in diabetic AMI group (P<005). Triglyceride (TG) levels and lowdensity lipoprotein cholesterol (LDLC) were significantly higher in diabetic AMI group compared with those in control group. A high incidence of low HDLC level was the most common dyslipidemia in all three groups. CONCLUSION: Diabetic AMI patients have significantly higher levels of blood glucose, HbA1C and dyslipidemia. Prevention and treatment of high serum glucose and lipid may lower the occurrence of AMI.