FHL2对心脏钾离子通道调控的研究进展

FHL2 regulation of cardiac potassium ion channels

摘要: FHL2蛋白是分子结构中仅含有4个半LIM结构域的蛋白质家族成员。LIM结构域是蛋白质——蛋白质相互作用的主要结构之一，可与多种蛋白结合成复合物发挥生物学功能。研究发现，FHL2能与多种蛋白质相互作用，如受体蛋白、结构蛋白、转录因子、信号转导蛋白及代谢酶类等。FHL2对某些基因的表达发挥调控作用。新近研究发现，FHL2蛋白参与了一些心脏钾离子通道的调控。本文就FHL2的结构特点、分布表达及其参与心脏钾离子通道调控的研究进展做一综述。

Abstract: FHL2 protein consists of four complete and one half LIM domains and belongs to a family that includes LIM domain only. LIM domains are proteininteraction domains and participate in multiple biological functions. Previous studies have shown that FHL2 interacts with a variety of proteins such as receptor proteins, structural proteins, transcription factors, signal transduction proteins and metabolic enzymes. FHL2 also regulates the expression of some genes. Recent studies indicated that FHL2 protein is involved in cardiac potassium ion channel regulation. This review summarizes the structure and expression of FHL2 and the regulation of cardiac potassium ion channels by FHL2.