Abstract: AIM:To evaluate value of the Global Registry of Acute Coronary Events (GRACE) scores for acute coronary syndrome (ACS) and prognostic prediction. METHODS: GRACE risk scores were graded and coronary artery angiography was performed in 212 hospitalized patients at our department between January 2007 and December 2009. Angiographic characteristics, the relationship between diabetes and GRACE scores and the incidence rate of 6month end event in different groups were analyzed. RESULTS: Significant differences of GRACE scores were observed in the number of pathological coronary arteries and the severity of lesions (P<005, P<001). No significant differences were observed in the incidence rate of 6month end event among the low, medium and highrisk groups. No significant differences were seen in the incidence rate of 6month end event between the groups with diabetes and without diabetes. CONCLUSION: GRACE scoring system has some predictive value with regard to the severity of lesions and the prognostic assessment of patients with coronary artery disease. Highrisk group accounts for a large proportion in patients with diabetes.