Abstract: Calcific aortic valve stenosis is widely prevalent in an aged population. In the past, calcific aortic valve stenosis was considered as a “benign” and passive process with aging due to its long asymptomatic period. Recently, calcific aortic valve stenosis is recognized as an active process and its development will ultimately lead to severe consequences. Once symptoms are developed in the late stage, the patient’s conditions can deteriorate quickly, leading to a poor prognosis with a high mortality. The standard therapy for severe calcific aortic valve is surgical aortic valve replacement; however, this procedure has its related surgical risks. There is no established way to retard disease progression and the most urgent research should be on its prevention and treatment.