Abstract: AIM To investigate the correlation between plasma IL-6, visfatin and severity of coronary stenosis in patients with coronary heart disease (CHD). METHODSA total of 128 patients with CHD confirmed by coronary angiography from our Department of Cardiology were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). Patients were divided into three groups according to the number of blood vessel lesions: single lesion group, double branch lesion group and three branch lesion group and were divided into three groups on the basis of the degree of coronary artery stenosis: 50%-75% group, 76%-90% group and 91%-100% group. Clinical data of these patients were collected. ELISA kits were used to measure plasma levels of IL-6 and visfatin. Gensini score was used to evaluate the severity of coronary artery stenosis. RESULTSPlasma levels of IL-6 and visfatin in ACS group were significantly higher than those in SAP group (P<0.05). Plasma levels of IL-6 and visfatin were significantly different in patients grouped by the number of blood vessel lesions and degree of coronary artery stenosis (P<0.05). Correlation analysis showed that IL-6 and visfatin were positively associated with Gensini score (r=0.583 and 0.724, respectively, both P<0.01). CONCLUSIONPlasma IL-6 and visfatin are closely associated with the severity of coronary artery stenosis.