Abstract: AIM: To investigate the clinical therapeutic efficacy of telmisartan combined with simvastatin in patients with congestive heart failure (CHF). METHODS: A total of 132 patients with CHF were randomly divided into group A (routine treatment group), group B (simvastatin treatment group) and group C (telmisartan+simvastatin treatment group). The clinical therapeutic efficacy as well as LVEDD, LVESD, LVEF and E/A were analyzed before and 180 days after treatment. RESULTS: Significant differences were found in the clinical therapeutic efficacy and left ventricular functions among the three groups before treatment and 180 days after treatment (P<0.05). In group B and group C, left ventricular functions improved more significantly than in group A (P<0.05). In group C, left ventricular function obviously increased, compared with group B (P<0.05). CONCLUSION: Combined administration of telmisartan and simvastatinv exerts better effects on patients with CHF than a single administration of simvastatin (P<0.05).