Abstract: AIM To observe the clinical effect of Benner Pury in patients with chronic pulmonary heart disease (CPHD) complicated with heart failure during acute exacerbation. METHODS Ninety exacerbated CPHD cases complicated with heart failure were randomly divided into treatment group and conventional group, with 45 cases in each group. The patients in the conventional group received conventional treatment of anti-infection, diuretics, oxygen, expectorant and tube expanding. Patients in the treatment group received conventional treatment plus Benner Pury. Blood gas analysis, heart functions and efficacy before and 8 weeks after treatment were compared between groups. RESULTS After treatment, arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SpO2) and pH significantly increased and arterial carbon dioxide partial pressure (PaCO2) decreased significantly in both groups. Stroke volume (SV), left ventricular ejection fraction (LVEF), cardiac output (CO), pulmonary artery pressure (PAP) and cardiac index (CI) were significantly better than those before treatment (P<0.05). Compared with those in the conventional group, SV, LVEF, CO and CI in the treatment group increased significantly and PAP decreased significantly (P<0.05). The effective rate in the treatment group was significantly higher (69% vs. 42%) and no effective rate was significantly lower (6.67% vs. 20%) than those in conventional group (P<0.05). The total effective rate in the treatment group was higher than in the conventional group (93% vs. 80%), but no significant difference was found between groups. CONCLUSION Conventional therapy combined with Benner Pury can significantly improve cardiac functions and effective rate in COPD patients complicated with heart failure during acute exacerbation.