Abstract: The mortality of patients with acute myocardial infarction (AMI) has greatly decreased due to the extensive development of percutaneouse coronary intervention and coronary artery bypass graft. However, patients who experience AMI are at increased risk of recurrent myocardial infarction (RMI). The underlying etiology of RMI is unclear but may be related to the inflammatory response. This review aims to elucidate the relationship between inflammatory response and RMI.