Abstract: AIM:To study the surgical treatment of patients with congenital heart disease (CHD) with severe pulmonary hypertension (PH). METHODS: One-way valved patch was used during surgical treatment for 48 patients with CHD with PH. Patients included represented 30 cases of ventricular septal defect (VSD), three cases of atrial septal defect (ASD), eight cases of VSD with ASD, and seven cases of VSD with patent ductus arteriosus (PDA). RESULTS: One patient died postoperatively due to low cardiac output syndrome. All patients suffered from hypoxia postoperatively. After the first postoperative week, transpatch shunt was observed in 40 patients and after 3 postoperative months, open valves were seen in ten cases. Twenty-six months postoperatively, valves closed and shunting disappeared. Transcutaneous oxygen was >95% and pulmonary artery pressure decreased significantly. CONCLUSION: Application of one-way valved patch in surgical treatment of congenital heart disease with pulmonary hypertension enhances the rate of successful surgeries and more rapid recovery.