顾晓龙, 龚志华, 邱健. 替罗非班对急性冠脉综合征患者PCI术后MMP-9及IL-6水平的影响[J]. 心脏杂志, 2011, 23(2): 235-237.
    引用本文: 顾晓龙, 龚志华, 邱健. 替罗非班对急性冠脉综合征患者PCI术后MMP-9及IL-6水平的影响[J]. 心脏杂志, 2011, 23(2): 235-237.
    shu
    Effect of tirofiban on levels of MMP-9 and IL-6 in acute coronary syndrome patients after percutaneous coronary intervention[J]. Chinese Heart Journal, 2011, 23(2): 235-237.
    Citation: Effect of tirofiban on levels of MMP-9 and IL-6 in acute coronary syndrome patients after percutaneous coronary intervention[J]. Chinese Heart Journal, 2011, 23(2): 235-237.
    shu

    替罗非班对急性冠脉综合征患者PCI术后MMP-9及IL-6水平的影响

    Effect of tirofiban on levels of MMP-9 and IL-6 in acute coronary syndrome patients after percutaneous coronary intervention

      摘要
    • 摘要: 目的: 观察替罗非班对急性冠脉综合征(ACS)患者经皮冠状动脉成形术(PCI)术后基质金属蛋白酶-9(MMP-9)及白介素-6（IL-6）水平的影响。方法： 选择我院2007年2月~2008年12月住院的ACS患者68例，随机分为对照组(n=34)和替罗非班组(n=34)。两组均急诊行PCI术，分别于PCI术前及术后12 h，用ELISA法检测患者血清MMP-9及IL-6的水平。结果： 替罗非班组与对照组相比,PCI术前两组之间MMP-9及IL-6的差异无统计学意义；PCI术后12 h，二者MMP-9的水平［(492±65) vs.(560±82)μg/L］和IL-6的水平［(46.0±7.2) vs.(59.7±8.2)ng/L］差异明显(P<0.05)。结论: 血小板GPⅡb/Ⅲa受体拮抗剂替罗非班能显著降低ACS患者介入术后MMP-9及IL-6的水平，抑制炎症反应，从而对血管具有一定的保护作用。

       

      Abstract: AIM: To investigate the effect of tirofiban on the levels of MMP-9 and IL-6 in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI). METHODS: A total of 68 ACS patients in our hospital from February 2007 to December 2008 were randomly divided into tirofiban group (n=34) and control group (n=34). All patients received emergency PCI. Venous blood samples were taken before and 12 h after PCI in both groups and serum samples were analyzed for MMP-9 and IL-6 by ELISA method. RESULTS: No significant difference was observed in the levels of MMP-9 and IL-6 before PCI between the two groups, but the levels of MMP-9 ［(492±65) vs.(560±82) μg/L］ and IL-6 ［(46.0±7.2) vs.(59.7±8.2) ng/L］ in the tirofiban group 12 h after PCI were significantly lower than those in the control group (P<0.05). CONCLUSION: Tirofiban protects the coronary artery by decreasing the levels of MMP-9 and IL-6 after PCI and suppressing inflammatory reaction in ACS patients.

       

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