Abstract: In recent years, morbidity and mortality due to alcoholic cardiomyopathy (ACM) have augmented with the increasing intake of alcoholic beverages. It is confirmed that the development of ACM involves the regulation of multiple factors. Moreover, endoplasmic reticulum stress, which is the key regulatory site of cell signaling, is documented to take part in the development of ACM. In this article we briefly review the overview, pathogenesis of ACM and role of endoplasmic reticulum stress in myocardial injury of alcohol consumption.