Abstract: AIM:To study the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and prognosis in patients treated with primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI). METHODS: Two hundred and fifteen patients treated with primary PCI after AMI from January 2007 to January 2011 were reviewed and their plasma hs-CRP levels were studied. Plasma hs-CRP concentrations were compared between patients who had a cardiovascular (CV) event and those without. Patients were divided into different groups according to their plasma hs-CRP concentration, and the CV event incidences were compared between groups. RESULTS: A significant difference was found in hs-CRP levels between patients with a CV event and patients without (10±4) mg/L vs. (6±5) mg/L, P<0.05). CV event incidences in various hs-CRP level groups were, respectively, hs-CRP 0-3 mg/L 23%, hs-CRP 3-6mg/L 24%, hs-CRP 6-9mg/L 47%, hs-CRP 9-12mg/L 52%, and hs-CRP 12-15mg/L 70%. Logistic regression analysis showed that the hs-CRP level was significantly related to the incidence of CV event, after correction for gender and age. CONCLUSION: hs-CRP is a prognostic factor in patients treated with primary PCI after AMI, the higher the hs-CRP, the higher the rate of CV event.