肖春晖, 杨向军, 张邢炜, 陈玉林, 励伟芬, 王利波, 薛树仁. 血浆脑钠尿肽水平与冠状动脉支架植入术后再狭窄有关[J]. 心脏杂志, 2010, 22(3): 386-389.
    引用本文: 肖春晖, 杨向军, 张邢炜, 陈玉林, 励伟芬, 王利波, 薛树仁. 血浆脑钠尿肽水平与冠状动脉支架植入术后再狭窄有关[J]. 心脏杂志, 2010, 22(3): 386-389.
    shu
    Plasma brain natriuretic peptide in predicting in-stent restenosis[J]. Chinese Heart Journal, 2010, 22(3): 386-389.
    Citation: Plasma brain natriuretic peptide in predicting in-stent restenosis[J]. Chinese Heart Journal, 2010, 22(3): 386-389.
    shu

    血浆脑钠尿肽水平与冠状动脉支架植入术后再狭窄有关

    Plasma brain natriuretic peptide in predicting in-stent restenosis

      摘要
    • 摘要: 目的: 探讨冠心病患者血浆脑钠尿肽(BNP)水平与冠状动脉支架内再狭窄的关系。方法: 选择317例接受冠状动脉支架植入术（PCI）以及术后1年内再次接受冠状动脉造影(CAG)检查的患者，分为再狭窄和无再狭窄组，分别在PCI术前、出院前和复查CAG前测定血浆BNP水平，两组患者分别比较相应的BNP水平。结果: 再狭窄组PCI术前、出院前及复查CAG前的BNP水平与无再狭窄组分别进行比较，差异有统计学意义（P<0.05），多因素logistic回归分析结果，血浆BNP水平是预测再狭窄的独立危险因子（均P<0.01）。结论: 血浆BNP水平与PCI术后再狭窄密切相关，有可能作为再狭窄的有用预测指标。

       

      Abstract: AIM: To study the relationship between brain natriuretic peptide (BNP) and intracoronary in-stent restenosis. METHODS: A total of 317 patients with acute coronary syndrome (ACS) or stable angina pectoris (SAP) successfully treated with percutaneous coronary stent implantation (PCI) were examined with a follow-up coronary angiography. Study subjects were divided into in-stent restenosis (ISR) group and no ISR group. Blood samples for BNP were obtained before PCI, at hospital discharge and during angiographic follow-up. RESULTS: Patients with restenosis had significantly higher plasma BNP levels than their counterparts without restenosis (P<0.05). Multivariate logistic regression analysis revealed that high plasma BNP level was an independent predictor of ISR. CONCLUSION: Plasma BNP level can be used as a predictive factor for restenosis after PCI.

       

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