舒血宁对不稳定型心绞痛患者CRP和MMP-9的影响

程景林; 万 俊

舒血宁对不稳定型心绞痛患者CRP和MMP-9的影响

程景林,
万俊

Influence of shuxuening on high-sensitivity C-reactive protein and matrix metalloproteinase-9 in patients with unstable angina pectoris

摘要

摘要: 目的:观察经舒血宁治疗后，不稳定型心绞痛（unstable angina pectoris,UAP）患者体内高敏C反应蛋白（high sensitivity C-reactive protein,hs-CRP）和基质金属蛋白酶9(matrix metalloproteinase-9，MMP-9)水平的变化。方法:100例UAP患者随机分为试药组和对照组，各50例。对照组给于常规治疗，试药组在此基础上加用舒血宁30 ml溶于250 ml 50 g/L葡萄糖注射液中静脉滴注，1次/d，连续治疗两周。在入院时、入院后12 h、24 h、48 h、7 d及14 d抽取外周血，检测各组患者hs-CRP和MMP9表达水平变化。结果:两组UAP患者外周血hs-CRP水平在入院后均开始升高，于24 h达高峰，24 h后逐渐下降；两组MMP-9水平入院后12 h达高峰，后逐渐下降；与对照组相比，试药组hs-CRP和MMP-9水平在入院后12 h、24 h、48 h、7 d及14 d均显著降低。结论:舒血宁可显著降低UAP患者体内hs-CRP和MMP-9表达水平。

Abstract: AIM:To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS: A 1∶1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info (6.04) and SPSS (15) were used for the logistic regression analysis of single and multiple factors, and the adjusted odds ratio of each factor (OR) and 95% confidence limit (CI) were calculated. RESULTS: Single factor analysis found that hyperlipidemia, diabetes, high C-reactive protein, transient ischemic attack (TIA), obesity, smoking and alcoholism were related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION: The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors.

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