Abstract: Hereditary channel disorder is closely related to dysfunction of excitable tissue such as the heart, brain and muscle. LQT2 is a hereditary heart disease caused by the mutation of the HERG gene, which encodes the ion channel and LQT2 typically presents with syncope, seizures, or sudden death. Previous research has shown that the concentration changes of the second messenger, cAMP, can regulate the expression of the channel protein. Human idiopathic epilepsy is an abnormal discharge of brain neurons caused by the dysfunction of the ion channel protein encoded by a mutant gene. The common clinical manifestation is clonus, syncope and sudden death. In the light of the current status of international and national research, this review will summarize the pathogenic relationship between LQT2 and epilepsy.