Abstract: AIM To investigate the correlation between the non-invasive Duke treadmill score (DTS) and the corrected thrombolysis in myocardial infarction frame count (CTFC) in patients with coronary atherosclerotic heart disease. METHODS A total of 61 patients with coronary atherosclerotic heart disease, who underwent treadmill exercise tests at least 2 weeks before coronary angiography, were enrolled in our study. According to the value of DTS, we divided patients into 2 groups: low-risk group (DTS≥5) and moderate-high-risk group (DTS<5), and the correlation between DTS and CTFC was evaluated. RESULTSDTS correlated negatively with CTFC of left anterior descending (LAD), left circumflex artery (LCX) and right coronary artery (RCA) (r=-0.834,-0.769,-0.698,P<0.01). CTFC in the low-risk group was much lower than that in the moderate-high-risk group \LAD: (21.3±1.7) vs (24.1±2.2), LCX: (26.9±2.6) vs (30.6±3.4), RCA:(21.1±4.0) vs (25.1±4.3), P<0.01\. CONCLUSION There is a negative correlation between DTS and CTFC of LAD, LCX and RCA in patients with CAD. The risk stratification on the basis of DTS is notably associated with CTFC.