Abstract: AIM:To observe the curative effect and safety of valsarton on unstable angina pectoris (UAP). METHODS: One hundred and twenty UAP patients were randomly divided into two groups: normal control group and valsartan group. For 6 months, patients in normal control group were given conventional treatment (nitrate acid ester, aspirin, β-receptor blocker and statins) and patients in valsartan group were given conventional treatment plus valsartan (40-80 mg/qd). Changes in clinical symptoms of angina, anginal attack frequency, electrocardiogram of ST-T segment, blood pressure and left ventricular hypertrophy were observed. RESULTS: Clinical symptoms of angina in the two groups were assuaged, attack frequency decreased, ST depression was reduced and left ventricular hypertrophy was reversed (P<0.05). Blood pressure of the two groups decreased (P<0.05) but with no significant difference between groups. CONCLUSION: On the basis of conventional therapy, valsartan has a reliable curative effect, good safety, more tolerance and few side effects in treatment of patients with UAP.