Abstract: AIM:To investigate the correlation between cardiovascular risk factors and coronary artery stenosis. METHODS: A total of 324 patients who underwent coronary angiography were selected from the People’s Hospital of Wuhan University from January 2010 to June 2010. There were 264 cases confirmed with coronary heart disease (CHD) (81.5%) and 60 cases without CHD (18.5%). Degree of coronary artery disease was assessed by the number of diseased vessels and total Gensini score. Data collected included gender, age, hypertension, diabetes, smoking, body mass index (BMI), cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), heart rate (HR), QT interval dispersion (QTd), coronary lesion count and total Gensini scores. Uni- and multivariate analyses were conducted. RESULTS: Univariate analysis showed that in groups of different lesions, coronary angiographic lesions and total Gensini score increased with the percentage increase of single risk factors. Multivariate logistic regression analysis (forward method) showed that increased QTd was the most significant independent risk factor for CHD (OR=4.2, 95% CI 3.8, 4.4, P<0.01), and other risk factors were low HDL-C, increased BMI, smoking, age, diabetes, high LDL-C, hypertension, high TC, high TG, increased HR, and male gender. CONCLUSION: Increased QTd is the most significant independent factor for CHD. Other risk factors such as low HDL-C, increased BMI, smoking, aging, diabetes, high LDL-C, hypertension, high TC, high TG, increased heart rate, and male gender should not be ignored.