Abstract: AIM To investigate the characteristic phenotype of electrocardiogram (ECG) in patients with hypertrophic cardiomyopathy (HCM). METHODS 60 inpatients with HCM from May 2015 to April 2017 in Xijing hospital were enrolled in the study. Another 60 patients (gender and age and weight matched in Xijing hospital) were chosen as a control group. 12-leads body surface ECGs were analysed, including QRS duration, R wave and S wave amplitude, abnormal q wave, duration of QTC, R/S ratio, ST segment elevation and depression, T wave low and inversion, and P wave duration. RESULTS In the HCM group, QRS duration in V2 and V3 leads, abnormal Q wave proportion in Ⅱ and V4 leads, QTC duration, P wave duration and ECG diagnosis of left ventricular hypertrophy were significantly greater than those in the normal control group.In the HCM group, QRS duration in I, aVR, aVL and aVF leads, and Q wave proportion in aVR leads, and QRS main wave direction consistent with T wave in I, Ⅱ, Ⅲ, aVL, aVF, V3, V4, V5, V6, and R/S ratio in V4, V5 and V6 leads were significantly less than those in the control group. CONCLUSION Differences in the HCM group were seen when compared to the control group. Additional differences in ECG were seen when compared to the control group. Further research is warranted to appreciate the significance of these differences.