Abstract: Mitral regurgitation is one of the most common valve disease. In recent years, progress has been made in the field of transcatheter mitral valve implantation. Up to now, transcatheter mitral valve implantation has been applied in clinical practice and there were few reports of various devices. More than 20 companies together with medical centers are developing different types of transcatheter mitral valve devices. In this paper, we reviewed the feasibility, safety and efficacy of transcatheter mitral valve implantation. The preliminary results indicate that it has good safety and effectiveness. Although there are still some problems to be solved, we believe that with the in-depth study, transcatheter mitral valve replacement will gradually mature. With new breakthroughs in the treatment of mitral valve, more and more patients will benefit from this mini-invasive approach. This comprehensive review focus mainly on the feasibility and safety of transcatheter mitral valve implantation.