Abstract: AIM Observation and analysis of the early high mobility group protein B1 level, to explore the correlation between early HMGB1 levels and heart failure in patients with acute myocardial infarction (AMI) proceeding emergency percutaneous coronary intervention (PCI). METHODS retrospective analysis in AMI patientswith 86 cases, divided into heart failure group (n=17) and control group (n=69). All patients collected elbow vein in admitted to hospital immediately and heart failure occured respectively to measure concentration of N-terminal probrain natriuretic peptides (NT-proBNP), and concentration of HMGB1 in admitted to hospital immediately.In admitted to hospital immediately and the onset of heart failure in 24 hours for cardiac doppler echocardiography, record the left ventricular ejection fraction (LVEF), early diastolic blood flow peak velocity/late diastolic blood flow peak velocity (E/A) ratio and cardiac output and output per minute.Analysis of plasma HMGB1 levels and the NT-proBNP level, the relationship between the cardiac function and plasma NT-proBNP level and cardiac output, per minute output reflect cardiac function, LVEF, E/A ratio of the correlation between the numerical. RESULTS compared with control group, echocardiography four indicators in the heart failure group were lower, while early HMGB1 levels rise, the difference had statistical significance (P<0.05). HMGB1 levels and occurred in patients with heart failure was positively related to the level of the NT-proBNP and every cardiac output, LVEF, per minute output, E/A ratio negatively correlated.Binary Logistic regression analysis: the plasma levels of HMGB1 and AMI underwent emergency PCI in patients with cardiac function has significant positive correlation. CONCLUSION There were obvious correlation between early HMGB1 levels and heart failure in patients with AMI proceeding PCI.