Abstract: AIM To analyse the risk factors and clinical characteristics of acute myocardial infarction (AMI) complicated with acute ischemic stroke (AIS). METHODS A retrospective analysis was carried out in 75 patients with AMI complicated with AIS in our hospital from January 2010 to April 2015, and clinical date of 80 cases with AMI and 80 cases with AIS were analyzed. RESULTS Single factor analysis showed that compared with the AMI group, patients with AMI complicated with AIS were significantly higher in history of ischemic stoke, history of Peripheral Artery Disease (PAD), serum creatinine (Cr), and were significantly decreased in high-density lipoprotein cholesterol (P<0.05). Compared with the AIS group, patients with AMI complicated with AIS were significantly higher in male, history of myocardial infarction, PAD, Cr, and were significantly lower in systolic blood pressure (SBP) and diastolic blood pressure (DBP, P<0.05). Logistics regression analysis showed that the independent risk factors are male, higher in history of ischemic stoke, Cr (P<0.05, OR>1), and DBP is a protective factor (P<0.01, OR<1). Clinical characteristics analysis showed that patients with AMI complicated with AIS are significantly higher in Killip classification ≥Ⅱ (44% vs. 16% vs. 1%, P<0.01) and multi-cerebral infarction (46% vs. 16%, P<0.01), and patients after PCI are significantly higher in coronary artery triple vessel lesion (76% vs. 52%, P<0.05). CONCLUSION The incidence risk factors of AMI complicated with AIS are male, decrease of DBP in admission, history of ischemic stoke, increase of serum creatinine, and cardiac dysfunction, multi-cerebral infarction as its clinical characteristics. Coronary artery triple vessel lesion is the clinical characteristics in patients after PCI.