Abstract: AIM To investigate the association between serum uric acid(SUA) and prognosis in patients with severe congestive heart failure(CHF). METHODS One hundred and eighty-nine consecutive patients with severe CHF hospitalized from April 2014 to January 2015 were included and the incidence of all-cause mortality during 6 months was observed. Statistical analyses were performed using SPSS 17.0. RESULTS Compared with the control group, uric acid level was significantly increased in all-cause mortality group(514±30) vs.(432±32) μmol/L, P<0.01. Pearson related analysis indicated that the uric acid level was positively related to NT-proBNP(r=0.345, P<0.05). Multiple logistic regression analysis found that uric acid levels(OR=1.213, 95%CI:1.081-3.621, P<0.05), NT-proBNP(OR=1.456, 95%CI:1.113-5.432, P<0.01) and diabetes(OR=2.105, 95%CI:1.221-4.553, P<0.05) were the independent risk factors for all-cause mortality within 6 months in severe CHF patients. CONCLUSION SUA level is associated with the prognosis in patients with severe CHF.