糖尿病性心肌病心肌纤维化治疗的进展

New therapeutic developments for fibrotic disease in diabetic cardiomyopathy

摘要: 糖尿病性心肌病(DCM)是继发于糖尿病(DM)的一种特异性心肌病,可引发心肌肥大、间质纤维化和心肌细胞凋亡。高血糖、肾素-血管紧张素-醛固酮系统(RAAS)系统、炎性因子和基质金属蛋白酶(MMP)的异常增多等多种因素与其发生机制有关。本文对近年DCM纤维化改变的治疗进展予以综述,以期为临床治疗提供依据。

Abstract: Diabetic cardiomyopathic changes include cardiac hypertrophy,interstitial fibrosis and apoptosis of cardiomyoctes. Hyperglycemia,renin-angiotensin-aldosterone system( RAAS),inflammatory factors and matrix metalloproteinases are believed to be associated with diabetic cardiac fibrosis disease. This article reviews new therapeutic developments for diabetic myocardial fibrosis.