Abstract: AIM: To retrospectively analyze the clinical and imaging features of myocardial bridge combined with severe atherosclerotic lesions in the segments proximal to the myocardial bridge and to compare the features with those of only myocardial bridge. METHODS: The study population( 192 patients)consisted of two groups: CHD group of 92 patients with severe atherosclerosis lesion of luminal narrowing of ≥70% in the segments proximal to the myocardial bridge and the bridge group of 100 patients with symptomatic myocardial bridge lesion of systolic luminal narrowness. The clinical and imaging features of the two groups were compared. RESULTS: Mean age ( 58 ± 11) years vs.( 52 ± 10) year,systolic pressure( 157. 8 ± 9. 8) mm Hg vs.( 146. 1 ± 10. 2) mm Hgand ratios of hyperlipidemia( 36 vs. 15%)in the CHD patients were higher than those in the bridge group. The mean levels of Chol ( 5. 9 ± 1. 8)mmol / L vs.( 4. 7 ± 1. 2) mmol / L and LDL ( 4. 3 ± 1. 4) mmol / L vs.( 3. 0 ± 1. 1) mmol / L in the CHD group were also higher than those in the bridge group( P < 0. 05). There was a significant difference in the extent of diameter stenosis during systolic stage between groups ( 74 ± 10) % vs.( 67 ± 9) %.CONCLUSION: Patients with severe atherosclerosis lesion in the segments proximal to the myocardial bridge have more CHD risk factors and the extent of diameter stenosis during systolic stage has some promoting effect on CHD development.