Abstract: AIM: To evaluate the safety and efficacy of percutaneous coronary intervention( PCI) for unprotected left main coronary artery( UPLMCA) disease. METHODS: Clinical data of 32 patients with UPLMCA disease who received PCI from September 2009 to August 2013 were analyzed retrospectively.RESULTS: Of the 32 cases,there were 11 cases of non-bifurcation lesion and 21 cases of bifurcation lesion. Stent implantations were performed in all patients,including 23 cases of single stent,five cases of single stent plus kissing balloon and four cases of double stents. Intraoperative vagal reflex occurred in one case and side branch occlusion-induced small area myocardial infarction occurred in one case. One patient( SYNTAX score 37) died from subacute stent thrombosis 4 days after PCI. All patients were followed up for 21. 53 ± 12. 89 months. Death occurred in one case( 3. 13%) and target vascular remodeling because of stent restenosis in three cases( 9. 38%) during the follow-up period. The total occurrence of major adverse cardiac and cerebrovascular events during hospitalization and follow-up periods was 18. 75%( 6 /32).CONCLUSION: PCI for selected patients with UPLMCA disease is safe and feasible and produces good short-and medium-term efficacy.