NADPH氧化酶亚基在心脏重构中作用的比较

Contrasting roles of NADPH oxidase isoforms in cardiac remodeling

摘要: 早期研究证实,烟酰胺腺嘌呤二核苷酸(还原型辅酶Ⅱ,NADPH)氧化酶在血管紧张素Ⅱ(AngⅡ)介导的心室重构中发挥重要作用,随着对NADPH氧化酶的深入研究,发现其共有5种亚基和两种相关的亚基,其中在心脏组织中表达的主要为Nox2与Nox4。Nox2在AngⅡ、心肌梗死及阿霉素介导的心室重构中具有重要的促进作用,而在压力负荷过大时引起的左心室肥大中Nox4 mRNA表达上调明显,由此可得出NADPH氧化酶亚基Nox2与Nox4在心室重构中的作用不同。因此,深入研究NADPH氧化酶亚基及其在心室重构中的作用,将成为改善心室重构新的治疗靶点。

Abstract: Early research demonstrated that NADPH oxidase was important in cardiac remodeling induced by angiotensin II(AngII).In later studies,a total of five NOX enzymes and two related enzymes were discovered and two main isoforms,Nox2 and Nox4,were found expressed in the heart.Nox2 could promote the development of cardiac remodeling induced by AngII,myocardial infarction and chemotherapeutic agent doxorubicin,whereas Nox4 mRNA increased significantly in pressure-overload left ventricular hypertrophy.Therefore,Nox2 and Nox4 play different roles in cardiac remodeling.A better understanding of these enzymes as well as their roles in cardiac remodeling may lead to new therapeutic targets based on modulation of Nox activity.