Abstract: AIM:To observe myocardial velocity and strain rate characteristics in patients with acute anterior wall myocardial infarction(MI) and to evaluate the clinical value of quantitative tissue velocity imaging(QTVI) and strain rate imaging(SRI) in quantitative assessment of left ventricular(LV) region infarction myocardial function.METHODS:Twenty patients with acute anterior wall MI and 30 control subjects were enrolled in the study.Longitudinal peak velocity,strain rate of LV anterior wall(AW) and anterior interventricular septum(AS) during systole,early diastole and atrium contraction(VS,VE,VA),(SRS,SRE,SRA) were measured at different levels(basal,middle and apical).QTVI and SRI data were compared with coronary angiography results.RESULTS:VS:different levels of LV infarction wall significantly decreased in acute MI(AMI) group;VE:all levels of LV infarction wall,except for apex levels of AS,were significantly lower than those in control group;VA:different levels of AW and apex level of AS in AMI group were significantly lower than those in control group;SRS and SRE:all levels of LV infarction wall in AMI group were significantly lower than those in control group;SRA:different levels of AW and base level of AS in AMI group were significantly lower than those in control group(P<0.05,P<0.01 respectively).CONCLUSION:QTVI and SRI are sensitive and feasible in evaluating functions of acute LV anterior wall myocardial infarction.