Abstract: AIM:To investigate the clinical significance and predictive value of high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-brain natriuretic peptide in patients with acute coronary syndrome(ACS) after primary percutaneous coronary intervention(PCI).METHODS:We summarized consecutive patients with ACS from February 2007 to April 2011 in Hunan Mawangdui Hospital and Changsha Central Hospital.A total of 101 ACS patients successfully underwent primary PCI and in whom plasma hs-CRP and NT-proBNP were measured,respectively,24 h,72 h-7 days and 3-6 months after PCI.Major adverse cardiac events(MACE) were observed during hospitalization and within 3-6 months after PCI.Plasma hs-CRP and NT-proBNP levels as well as incidence of MACE in 52 ACS patients in medically treated group and 40 healthy controls were also examined during the same period and compared with those in PCI group.RESULTS:Short-term plasma NT-proBNP levels in medically treated group were significantly higher than those in PCI group,but plasma hs-CRP levels within 72 h-7 days were significantly higher in PCI group compared with those in medicine treatment group.MACE in PCI group was lower than that in medically treated group.CONCLUSION:Both plasma hs-CRP and NT-proBNP are good predictors for mortality and MACE incidence in ACS patients treated with PCI or medications.hs-CRP is a short-term prognostic factor for ACS patients treated with primary PCI,whereas NT-proBNP is a long-term prognostic factor for ACS patients.