瑞舒伐他汀和替米沙坦对原发性高血压并发阵发性心房纤颤治疗的影响
Effects of rosuvastatin and telmisartan on patients with essential hypertension with paroxysmal atrial fibrillation
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摘要: 目的:观察瑞舒伐他汀和替米沙坦对原发性高血压(EH)并发阵发性心房纤颤(AF)患者心电图P波时限和离散度及AF发生率的影响。方法:EH并发阵发性AF患者56例,随机分为2组:替米沙坦(80 mg/d)加瑞舒伐他汀(10 mg/d)组(联合用药组)和替米沙坦(80 mg/d)组。共观察6个月。分别于用药前后测定12导联体表心电图中P波的时限和P波离散度及AF发生率。结果:用药后两组均可使EH并发阵发性EH患者心电图P波的时限和P波离散度减小,组间比较显示,联合用药组的作用优于单用替米沙坦组。结论:瑞舒伐他汀合用替米沙坦对EH并发阵发性AF患者窦律的维持及预防AF发生的作用优于单用替米沙坦。Abstract: AIM:To study the effects of rosuvastatin and telmisartan on P-wave dispersion in eletrocardiography in patients with essential hypertension(EH).METHODS:Fifty-six patients were randomly divided into telmisartan(80 mg/day) plus rosuvastatin(10 mg/day) group and telmisartan(80 mg/day) group and were monitored for 6 months.P-wave duration and P-wave dispersion were detected before and after using the drugs.RESULTS:After using the drugs,P-wave duration and P-wave dispersion in both groups of patients with EH decreased(P<0.05).Compared with telmisartan alone,rosuvastatin plus telmisartan had more obvious effect on P-wave dispersion.CONCLUSION:Treatment with rosuvastatin and telmisartan has more effective value in preventing atrial fibrillation than using telmisartan only in patients with EH.
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