Abstract: With the deepening research of patent foramen ovale (PFO) in recent years, the evidence-based medical evidence of PFO-associated stroke is abundant, and its treatment strategy has been unanimously recognized both at home and abroad, and consensus or guidelines have been formulated successively. At present, in addition to interventional closure of PFO in patients with PFO-associated stroke, the number of patients with PFO combined with other diseases receiving PFO closure is also growing rapidly. However, the evidence-based medical evidence for PFO-related non-apoplectic disease is insufficient, and there is still a lack of guiding documents both at home and abroad. In order to standardize PFO interventional therapy, combined with the latest progress in the clinical application of PFO and clinical research both at home and abroad, after many discussions, the Structural Cardiology Committee of China Association for Promotion and Health Science and the Neurology Branch of the Chinese Medical Doctor Association organized domestic experts in related fields to form the "Chinese expert consensus on the prevention and treatment of patent foramen oval related non-apoplectic disease" .