AIM  To explore the construction and application of standardized intervention in the diagnosis of patent foramen ovale (PFO) by transesophageal echocardiography (TEE) combined with right cardiac contrast echocardiography.

  METHODS  From November 2020 to August 2022, 180 patients suspected of PFO underwent TEE combined with right heart sonography in the Second Affiliated Hospital of the Air Force Military Medical University were included in the study. The nursing staff participated in the whole process and provided standardized intervention, including personnel education, material preparation, guidance of Valsalva’s actions, synchronous cooperation measures related to examination, observation and recording after examination, so as to ensure the smooth completion of the examination.

  RESULTS  None of the 180 patients gave up TEE combined with right heart sonography because of fear and tension. 179 patients successfully completed TEE combined with right heart sonography under two states of calm breathing and Valsalva action. One patient was unable to complete the Valsalva action due to the sequelae of cerebral infarction, and only underwent right heart contrast echocardiography under calm breathing state. Two patients complained of dizziness and palpitation after the examination, which were relieved without special treatment.

  CONCLUSION  During the whole process of TEE combined with right heart contrast echocardiography, scientific, effective and standardized intervention is the key guarantee to better carry out relevant examinations.