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离子通道在糖尿病心肌病中研究新进展

靳嘉岩 刘赫 曹桂花 刘艳 王晓明 侯莉明

靳嘉岩, 刘赫, 曹桂花, 刘艳, 王晓明, 侯莉明. 离子通道在糖尿病心肌病中研究新进展[J]. 心脏杂志, 2023, 35(1): 83-87. doi: 10.12125/j.chj.202206040
引用本文: 靳嘉岩, 刘赫, 曹桂花, 刘艳, 王晓明, 侯莉明. 离子通道在糖尿病心肌病中研究新进展[J]. 心脏杂志, 2023, 35(1): 83-87. doi: 10.12125/j.chj.202206040
Jia-yan JIN, He LIU, Gui-hua CAO, Yan LIU, Xiao-ming WANG, Li-ming HOU. Research progress of alternations of ion channels in diabetes cardiomyopathy[J]. Chinese Heart Journal, 2023, 35(1): 83-87. doi: 10.12125/j.chj.202206040
Citation: Jia-yan JIN, He LIU, Gui-hua CAO, Yan LIU, Xiao-ming WANG, Li-ming HOU. Research progress of alternations of ion channels in diabetes cardiomyopathy[J]. Chinese Heart Journal, 2023, 35(1): 83-87. doi: 10.12125/j.chj.202206040

离子通道在糖尿病心肌病中研究新进展

doi: 10.12125/j.chj.202206040
基金项目: 国家重点研发计划项目(2020YFC2008000);陕西省重点研发计划项目(2021SF-037)
详细信息
    作者简介:

    靳嘉岩,本科生 Email:2846653686@qq.com

    通讯作者:

    侯莉明,主治医师,博士,主要从事老年心血管疾病基础与临床研究 Email:houlm11@163.com

  • 中图分类号: R587.2

Research progress of alternations of ion channels in diabetes cardiomyopathy

  • 摘要: 糖尿病性心肌病(diabetes cardiomyopathy,DCM)是继发于糖尿病的一种特异性心肌病,其独立于高血压性、冠状动脉粥样硬化性或其他原因所致心脏病。DCM以心肌代谢紊乱和心脏微血管病变为基础,导致广泛的局灶性心肌坏死,随后发展为收缩功能障碍,最终表现为心力衰竭。离子通道在维持心肌细胞膜电位、信号传导、心肌细胞代谢方面发挥着重要作用,近年来的研究发现,钙、钾、钠等阳离子通道以及阴离子通道的改变是糖尿病心肌病发病的重要基础。本文从离子通道这一视角出发,系统性综述了糖尿病心肌病研究新进展。

     

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出版历程
  • 收稿日期:  2022-06-16
  • 修回日期:  2022-08-13
  • 网络出版日期:  2022-10-17
  • 刊出日期:  2023-02-25

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