Abstract: N6-methyladenosine (m⁶A) RNA methylation is the most common, dynamic and reversible epigenetic RNA modification and is involved in the pathogenesis of many human diseases, including cardiovascular diseases. Recent studies have shown that m⁶A RNA methylation plays an important regulatory role in myocardial ischemia-reperfusion and cardiac regeneration. Importantly, these new findings suggest that controlling m⁶A levels by altering the regulatory factors of m⁶A may be a novel and powerful strategy to prevent the deterioration of cardiac functions and promote cardiac repair.