AIM  To evaluate the effect of potassium-magnesium aspartate on serum potassium levels and QTc interval in patients after coronary angiography.

  METHODS  The study subjects were from the cardiovascular department of Tianjin People’s Hospital from January 2019 to November 2020.282 patients with coronary angiography were selected and divided into the magnesium-potassium aspartate group (138 cases) and the potassium chloride group (144 cases).The magnesium-potassium aspartate group was treated with 30ml magnesium-potassium aspartate and the potassium chloride group with 0.5g potassium chloride before operation. Such changes of index were observed as serum potassium, sodium, chloride, serum creatinine, red blood cells, hemoglobin, red blood cell hematocrit, QTc (QT interval corrected) . Gensini scores were calculated in order to evaluate the extent of QTc prolongation in patients after coronary angiography, its relationship to coronary lesions and electrolytes.

  RESULTS  In the potassium magnesium aspartate treatment group, serum potassium ion, hemoglobin, erythrocyte count, platelet count and hematocrit were lower than those before operation (all P<0.01), while serum sodium ion, chloride ion, serum creatinine and QTc interval were higher than those before operation (all P<0.01); There was no significant difference in platelet volume between before and after operation. In potassium chloride group, serum potassium ion, hemoglobin, erythrocyte count, hematocrit and platelet were lower than those before operation (all P<0.01), serum sodium ion, chloride ion and QTc interval were higher than those before operation (all P<0.01), and there was no significant difference in serum creatinine and platelet volume; Compared with the potassium chloride group in the same period, the proportion of hypokalemia (P<0.05) and QTc in the potassium magnesium aspartate treatment group were lower than those before operation (P<0.01). Binary Logistic regression analysis showed that preoperative application of potassium magnesium aspartate was an independent protective factor for hypokalemia (P<0.01), and postoperative potassium ion level was an influencing factor for the prolongation of QTc compared with that before operation (P<0.05). QTc in postoperative patients was longer than that before operation, which was significantly negatively correlated with postoperative blood potassium level, negatively correlated with postoperative erythrocyte level (all P<0.05), and positively correlated with age (P<0.05).

  CONCLUSION   Treatment of magnesium-potassium aspartate can significantly decrease the incidence of hypokalemia,QTc prolongation and arrhythmias in patients after coronary angiography.