AIM   To explore the relationship between fibrinogen (FIB) level and premature coronary artery disease (CAD) and phlegm-dampness syndrome of premature CAD.

  METHODS  A total of 239 patients (male <55 years of age, female <65 years of age) admitted to the Department of Cardiology of Integrated Traditional Chinese and Western Medicine of China-Japan Friendship Hospital for coronary angiography from November 2019 to November 2021 were divided into premature CAD group (n=111) and non-CAD group (n=128). The patients in premature CAD group were further divided into phlegm-dampness syndrome group (n=56) and non-phlegm-dampness syndrome group (n=55). Clinical data of the above groups were compared. The relationship between FIB and premature CAD and phlegm-dampness syndrome of premature CAD were analyzed by logistic regression analysis and the value of FIB for predicting phlegm-dampness syndrome of premature CAD was analyzed by ROC curve analysis.

  RESULTS  The FIB level of the premature CAD group was higher than that of the non-CAD group (P<0.01). The FIB level of the phlegm-dampness syndrome group was higher than that of the non-phlegm-dampness syndrome group (P<0.05). Logistic regression analysis showed that FIB was associated with the prevalence of premature CAD (OR=1.85, 95% CI: 1.06～3.23, P<0.05), and the results of subgroup analysis were relatively stable. FIB was associated with phlegm-dampness syndrome of premature CAD (OR=1.73, 95% CI: 1.02～2.93, P<0.05). The area under the ROC curve of FIB in predicting phlegm-dampness syndrome of premature CAD was 0.63 (95% CI: 0.52～0.73, P<0.05).

  CONCLUSION  FIB is associated with premature CAD and with phlegm-dampness syndrome of premature CAD.