AIM   To study the correlation between hemorheology and blood lipid levels in patients with hyperhomocysteine (HHcy).

  METHODS  A total of 162 HHcy patients admitted to our hospital from December 2020 to November 2021 were selected for HHcy group and 309 subjects under routine physical examination during the same period served as control group. Serum homocysteine (hcy), hemorheology and blood lipid triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were detected in both groups. Twenty-seven patients who received folic acid and methcobalamin correction therapy were screened out, whose corresponding indicators were tested again a month after treatment, and the results were analyzed.

  RESULTS  The whole blood viscosity shear rates of 1,5,30,200 (mPa·s), total cholesterol, triglyceride and low density lipoprotein cholesterol in HHcy group were significantly higher than those in the control group, and high density lipoprotein cholesterol was significantly lower than those in the control group (all P<0.05). The results of multivariate logistic regression analysis showed that the whole blood viscosity shear rates of 1,5 (mPa·s) (all P<0.05); Triglyceride and low density lipoprotein cholesterol (all P<0.01) were the influencing factors of HHcy. After 4 weeks of corrective treatment with folic acid and Mecobalamin, the levels of Hcy, whole blood viscosity shear rate 1 and 5 (mPa·s), triglyceride and low density lipoprotein cholesterol decreased significantly (P<0.05).

  CONCLUSION  whole blood viscosity, shear rate 1,5 (mPa·s), triglyceride and low density lipoprotein cholesterol are the influencing factors of HHcy; Folic acid and Mecobalamin can reduce the level of Hcy and improve the indexes of hemorheological parameters 1,5 (mPa·s), triglyceride and low density lipoprotein cholesterol.