Abstract: Complex high-risk and indicated patients (CHIPs) are a group of patients with severe coronary artery disease who require revascularization and are at high risk for surgery. Current treatment strategies for CHIPs include optimal medical therapy, revascularization, and mechanical circulatory support (MCS). For CHIPs, optimal medical therapy is difficult to benefit patients significantly; percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) as the main means can partially or completely achieve coronary revascularization, improve patients' cardiac function and enhance the quality of survival, but requires highly individualized selection based on the current basic consensus. The role of MCS in coronary revascularization therapy has its advantages and disadvantages and needs to be appropriately selected for use. In addition, a multidisciplinary treatment team for CHIPs is essential in the treatment and management of CHIPs. This paper focuses on a review of clinical treatment options and related issues for CHIPs.