Abstract: Since the outbreak of COVID-19, online learning has become the new normal in most universities. The teaching of aerospace medicine courses is a professional and practical course. Based on our experience in organization of aerospace clinical medicine online teaching during the COVID-19 epidemic, this article summarizes the difficulties and challenges, and proposes the problems faced by online aerospace medicine teaching, including the lack of hardware and software in the use of online teaching platforms, the lack of interaction in online classrooms, the weakened real-time management of online classroom organization and discipline, and other difficulties and challenges. Corresponding strategies have been formulated. In order to better utilize online teaching in aerospace medicine teaching, the teaching concept must be changed, and the teachers much be fully aware of the shortcomings of online teaching, and actively implement the optimized measures to improve the quality of online teaching.