AIM  To apply two-dimensional speckle tracking technology (2D-STE) evaluating the effect of primary hyperparathyroidism (PHPT) on left ventricular function.

  METHODS  Thirty-one patients diagnosed with PHPT in our hospital were selected as the PHPT group. The 35 patients in the control group were selected as the control group. All patients underwent blood biochemistry, electrocardiogram, and routine echocardiography examination, at the same time collecting apical four-chamber heart, three-chamber heart, and two-chamber heart slices for analysis of 2D-STE images. The last ultrasonic parameters obtained include left atrial inner diameter (LAD), left ventricular end diastolic inner diameter (LVEDD), left ventricular end diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), ventricular septal thickness (IVS), left ventricular posterior wall thickness (LVPW), early and late diastolic blood flow velocity of the mitral valve (E, A), the average value of the early diastolic velocity of the mitral valve annulus and the left ventricular side wall (e'), calculate E/A and E/e', left ventricular global longitudinal strain (GLS) and left ventricular global longitudinal strain rate (GLSR).

  RESULTS  There was no significant difference in LAD, LVEDD, LVEDV, LVEF, IVS, LVPW, E, A, E/A between the control group and the PHPT group; e', the absolute value of GLS and the absolute value of GLSR in PHPT group were lower than the control group, E /e' was higher than the control group, the difference was statistically significant (P<0.05). The absolute value of GLS was negatively correlated with serum calcium and parathyroid hormone levels (r = −0.46, P<0.05)(r = −0.51, P<0.05). E/e’ was positively correlated with serum calcium and parathyroid hormone levels (r = 0.42, P<0.05)(r = 0.48, P<0.05).

  CONCLUSION  There is a good correlation between 2D-STE and PHPT left ventricular systolic function, which needs further study and application evaluation..