Abstract:
AIM Although neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) have been investigated higher in many inflammatory diseases, their roles in Takayasu Arteritis (TA) was still unclear. Herein, we evaluated NLR and PLR level in TA patients and their association with disease activity.
METHODS A retrospective study enrolled 55 adult patients with TA and 56 healthy individuals. Complete clinical and demographic characteristics of TA patients were obtained from their medical records. Similar data were extracted from the controls. The correlations between NLR, PLR and disease activity were analyzed.
RESULTS NLR and PLR were increased in TA patients as compared with those in healthy controls(2.58 ± 0.15 vs.1.87 ± 0.11, P<0.01; 175 ± 11 vs.119 ± 4, P<0.01).NLR was positively correlated with CRP(r = 0.36, P<0.05) and ESR (r = 0.37, P<0.05), and negtively correlated with Kerr score(r = −0.31, P<0.05). PLR was positively correlated with CRP(r = 0.65, P<0.01) and ESR (r = 0.76, P<0.01). The AUC for PLR was 0.706 (sensitivity 95%; specificity 45%), at a cut-off value of 163. The AUC for NLR was 0.726 (sensitivity 68%; specificity 78%), at a cut-off value of 1.88.
CONCLUSIOIN PLR and NLR could predict disease activity in TA patients.
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