Abstract:
AIM To investigate the correlation between serum levels of lipoprotein (a) (Lp(a)) and cystatin C (Cys C) and depression in patients with coronary heart disease(CHD).
METHODS 102 consecutive patients with CHD were studied. Basic clinical data and serum Lp(a) and Cys C levels were collected after admission. The subjects were divided into the depressed group and the non-depressed group based on Beck Depression Inventory (BDI). The difference in serum levels of Lp(a) and Cys C between the two groups was analyzed by student t-test. Linear regression and logistic regression were used to test the association between the two serum biomarkers with depression. ROC was performed to test the predictive accuracy of the two biomarkers.
RESULTS Serum levels of Lp(a) and Cys C were significantly higher in the depressed group compared with the non-depressed group (P<0.01), and they were positively correlated with the degree of depression in the patients with CHD. The results of multivariate logistic regression analysis showed that the serum levels of Lp(a) and Cys C were both independent risk factors for depression (OR=1.004, 95%CI: 1.001-1.008, P<0.01; OR = 32.715, 95% CI: 3.246-329.7373, P<0.01). The results of the ROC curve showed that the areas under the curve of Lp(a) and Cys C in the diagnosis of depression in CHD patients were 0.741(95%CI:0.647-0.835) and 0.719(95%CI:0.614 ~ 0.823), respectively. When the cut-off value of Lp(a) was 90.7mg/L, the diagnostic efficiency was highest, the sensitivity of 87.5%, and the specificity of 54.3%. When the cut-off value of Cys C was 0.98mg/L, the diagnostic efficiency was highest, the sensitivity of 75.0%, and the specificity of 54.4%.
CONCLUSION The serum levels of Lp(a) and Cys C in CHD patients with depression are significantly higher than those without depression., and positively correlated with depression degree. In addition, they are independent risk factors for depression in CHD patients.
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