Abstract: Heart failure (HF) is a clinical syndrome with high mortality and morbidity. Clinical data show that patients with HF have a higher risk of depression and nearly 30% of HF patients suffer from depression. Depression seriously lowers the quality of life and increases the risk of readmission and even death of HF patients. Currently, the mechanisms of HF combined with depression remain elusive. There lack effective therapies for HF combined with depression. Therefore, depression is still a neglected problem in the management of HF. This article summarizes the epidemiological data, prognosis and therapies of HF combined with depression.