苏海霞, 王晨光, 王春燕. 不同剂量利多卡因对腹腔镜子宫肌瘤切除术患者麻醉诱导时QTc的影响[J]. 心脏杂志, 2021, 33(2): 165-168. DOI: 10.12125/j.chj.202101079
    引用本文: 苏海霞, 王晨光, 王春燕. 不同剂量利多卡因对腹腔镜子宫肌瘤切除术患者麻醉诱导时QTc的影响[J]. 心脏杂志, 2021, 33(2): 165-168. DOI: 10.12125/j.chj.202101079
    shu
    Hai-xia SU, Chen-guang WANG, Chun-yan WANG. Effects of different doses of lidocaine on QTc interval in patients during anesthesia induction in laparoscopic hysteromyomectomy[J]. Chinese Heart Journal, 2021, 33(2): 165-168. DOI: 10.12125/j.chj.202101079
    Citation: Hai-xia SU, Chen-guang WANG, Chun-yan WANG. Effects of different doses of lidocaine on QTc interval in patients during anesthesia induction in laparoscopic hysteromyomectomy[J]. Chinese Heart Journal, 2021, 33(2): 165-168. DOI: 10.12125/j.chj.202101079
    shu

    不同剂量利多卡因对腹腔镜子宫肌瘤切除术患者麻醉诱导时QTc的影响

    Effects of different doses of lidocaine on QTc interval in patients during anesthesia induction in laparoscopic hysteromyomectomy

      摘要
    • 摘要:
        目的  分析不同剂量利多卡因对腹腔镜子宫肌瘤切除术患者麻醉诱导期间按心率校正的QT间期（QTc）的影响。
        方法  纳入2019年6月～2019年12月在山西医科大学第一医院行腹腔镜子宫肌瘤切除术的患者共80例，采用随机数字表法分配到4组（等容积但不同剂量利多卡因或生理盐水），分别为：A组（空白剂量组，生理盐水）、B组（低剂量组，利多卡因0.5 mg/kg）、C组（中剂量组，利多卡因1 mg/kg）及D组（高剂量组，利多卡因1.5 mg/kg），每组20例，在麻醉诱导后静脉注射。记录麻醉诱导前(T0)、诱导药给予2 min后(T1)、气管插管后1 min(T2)、气管插管后3 min(T3)及气管插管后6 min(T4)，5个时刻的动脉收缩压（SBP）、动脉舒张压（DBP）、平均动脉压（MAP）、心率（HR）及心电图（ECG）的QTc。
        结果  D组气管插管后SBP、DBP、MAP和HR未见明显波动，组内差异性小；麻醉诱导后各组QTc值均有延长，但D组在气管插管后的T2和T3时刻QTc值短于其他三组，一定程度上抑制了QTc的延长。
        结论  腹腔镜子宫肌瘤切除术患者麻醉诱导后高剂量组诱导期间血流动力学更稳定，可抑制麻醉诱导期间的QTc延长。

       

      Abstract:
        AIM  To evaluate the effect of different doses of lidocaine on QT interval (QTc) in patients during anesthesia induction in laparoscopic hysteromyomectomy.
        METHODS  Eighty patients with laparoscopic hysteromyomectomy were randomly divided into groups A (blank dose group), B (low dose group), C (medium dose group) and D (high dose group), with 20 cases in each group. After induction of anesthesia, groups B, C and D were intravenously infused with lidocaine (0.5 mg/kg, 1 mg/kg and 1.5 mg/kg respectively), while group A was intravenously infused with the same volume of saline. SBP, DBP, MAP, HR and ECG (QT interval) were recorded before anaesthesia induction (T0), 2 min after induction drug injection (T1) and 1, 3, 6 min after intubation (T2-4).
        RESULTS  There was no obvious fluctuation in SBP, DBP, MAP and HR after intubation in D group and the level of QTc in each group was prolonged after anesthesia induction, but the T2 time and T3 time in group D after intubation were shorter than those in the other three groups. To some extent, the prolongation of QTc was inhibited.
        CONCLUSION  Intravenous infusion of 1.5 mg/kg lidocaine to patients in laparoscopic hysteromyomectomy after induction of anesthesia can keep the stability of hemodynamics and inhibit QTc prolongation during anesthesia induction.

       

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